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Recent progress in molecular biology has revealed the underlying pathogenic mechanisms of many carcinomas. In particular, cellular oncogenes that are causative factors in the development of various carcinomas are identified. Melanoma is one of the most aggressive cancers. Although the incidence of melanoma has been increasing worldwide, the molecular mechanisms underlying the development of this cancer remain largely unknown. A large body of evidence shows that oncogenic BRAF mutation is a key event in the development of melanoma. Recent reports indicate that therapeutic drugs targeted to mutant BRAF may be effective in the treatment of patients with melanoma harboring this mutation. Progress in the genetics of melanoma has provided a valuable opportunity to develop novel molecular-targeted therapies for this deadly cancer.Unwired Planet Initiative
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